Clinical and Research Links
We will upload studies and provide commentary where possible.
Otherwise, here is a gathering of links to inositol related scientific publications...
PCOS STUDIES:
Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. Kai I Cheang 1, Jean-Patrice Baillargeon, Paulina A Essah, Richard E Ostlund Jr, Teimuraz Apridonize, Leila Islam, John E Nestler
https://pubmed.ncbi.nlm.nih.gov/18803944/
Strategy to improve the female fertility in the general gynecologist's office: use of a nutritional supplement based on myo-inositol/D-chiro-inositol and antioxidants
Nicolás Mendoza
https://www.tandfonline.com/doi/full/10.1080/09513590.2021.2015759?src=recsys
Myoinositol versus metformin pretreatment in GnRH-antagonist cycle for women with PCOS undergoing IVF: a double-blinded randomized controlled studyKeerthana Rajasekaran, Neena Malhotra, Reeta Mahey, Rajesh Khadgawat & Mani Kalaivani
https://www.tandfonline.com/doi/full/10.1080/09513590.2021.1981282?src=recsys
D-Chiro-inositol in PCOS: the myths and what we know about the reality :
Vittorio Unfer
https://www.tandfonline.com/doi/full/10.1080/09637486.2022.2089638
Nutraceuticals and polycystic ovary syndrome: a systematic review of the literatureDaniela Menichinihttps://www.tandfonline.com/doi/full/10.1080/09513590.2022.2089106?src=recsys
D-Chiro-inositol and PCOS: between myth and reality. The never-ending storyAntonio Cianci, Salvatore Giovanni Vitale https://pubmed.ncbi.nlm.nih.gov/35057707/
The menstrual cycle regularization following d-chiro-inositol treatment in PCOS women: a retrospective studyAntonio La Marca
https://www.tandfonline.com/doi/full/10.3109/09513590.2014.964201?src=recsys
Treatment with d-chiro-inositol and alpha lipoic acid in the management of polycystic ovary syndromeFranca Fruzzetti, Anna Capozzi, Alessandro Canu & Stefano Lellohttps://www.tandfonline.com/doi/full/10.1080/09513590.2018.1540573?src=recsys
Impact of myoinositol with metformin and myoinositol alone in infertile PCOS women undergoing ovulation induction cycles - randomized controlled trialPriyanka Prabhakar, Reeta Mahey, Monica Gupta, Rajesh Khadgawat, Garima Kachhawa, Jai Bhagwan Sharma, Perumal Vanamail, Rajesh Kumari & Neerja Bhatlahttps://www.tandfonline.com/doi/full/10.1080/09513590.2020.1810657?src=recsys Myo-inositol content of common foods: development of a high-myo-inositol diet. Am J Clin Nutr 1980 33: 1954-67. _R S Clements, Jr, and B Darnell. http://www.ncbi.nlm.nih.gov/pubmed/7416064
Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls. Biochem. Biophys. Res. Commun. 293 (3): 1092-8. _ Sun TH, Heimark DB, Nguygen T, Nadler JL, Larner J (2002). http://www.ncbi.nlm.nih.gov/pubmed/12051772
Role of inositolphosphoglycan mediators of insulin action in the polycystic ovary syndrome. J. Pediatr. Endocrinol. Metab. 13 Suppl 5: 1295-8. _ Nestler JE, Jakubowicz DJ, Iuorno MJ (2000). http://www.ncbi.nlm.nih.gov/pubmed/11117673
D-chiro-inositol its functional role in insulin action and its deficit in insulin resistance. Int. J. Exp. Diabetes Res. 3 (1): 47-60. _ Larner J (2002). http://www.ncbi.nlm.nih.gov/pubmed/11900279
Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. N. Engl. J. Med. 340 (17): 1314-20. _ Nestler JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G (1999). http://www.ncbi.nlm.nih.gov/pubmed/10219066 Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome. Endocrine practice 8 (6): 417-23. _ Luorno MJ, Jakubowicz DJ, Baillargeon JP, et al (2002). http://www.ncbi.nlm.nih.gov/pubmed/15251831 PANIC DISORDERS: 1. Stewart SA. The effects of benzodiazepines on cognition. J Clin Psychiatry. 2005;66(suppl 2):9-13. https://pubmed.ncbi.nlm.nih.gov/1576281 2. "Risks Associated with Long-Term Benzodiazepine Use" by BRIAN JOHNSON, MD, State University of New York Upstate Medical University, Syracuse, New York and JON STRELTZER, MD, University of Hawaii School of Medicine, Honolulu, Hawaii https://www.aafp.org/pubs/afp/issues/2013/0815/p224.html#afp20130815p2243. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorderJ Benjamin 1, J Levine, M Fux, A Aviv, D Levy, R H Belmaker PMID: 7793450 DOI: 10.1176/ajp.152.7.10 https://pubmed.ncbi.nlm.nih.gov/7793450/4. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorderA Palatnik 1, K Frolov, M Fux, J Benjam PMID: 11386498 https://pubmed.ncbi.nlm.nih.gov/1138649
Impact of myoinositol with metformin and myoinositol alone in infertile PCOS women undergoing ovulation induction cycles - randomized controlled trialPriyanka Prabhakar, Reeta Mahey, Monica Gupta, Rajesh Khadgawat, Garima Kachhawa, Jai Bhagwan Sharma, Perumal Vanamail, Rajesh Kumari & Neerja Bhatlahttps://www.tandfonline.com/doi/full/10.1080/09513590.2020.1810657?src=recsys Myo-inositol content of common foods: development of a high-myo-inositol diet. Am J Clin Nutr 1980 33: 1954-67. _R S Clements, Jr, and B Darnell. http://www.ncbi.nlm.nih.gov/pubmed/7416064
Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls. Biochem. Biophys. Res. Commun. 293 (3): 1092-8. _ Sun TH, Heimark DB, Nguygen T, Nadler JL, Larner J (2002). http://www.ncbi.nlm.nih.gov/pubmed/12051772
Role of inositolphosphoglycan mediators of insulin action in the polycystic ovary syndrome. J. Pediatr. Endocrinol. Metab. 13 Suppl 5: 1295-8. _ Nestler JE, Jakubowicz DJ, Iuorno MJ (2000). http://www.ncbi.nlm.nih.gov/pubmed/11117673
D-chiro-inositol its functional role in insulin action and its deficit in insulin resistance. Int. J. Exp. Diabetes Res. 3 (1): 47-60. _ Larner J (2002). http://www.ncbi.nlm.nih.gov/pubmed/11900279
Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. N. Engl. J. Med. 340 (17): 1314-20. _ Nestler JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G (1999). http://www.ncbi.nlm.nih.gov/pubmed/10219066 Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome. Endocrine practice 8 (6): 417-23. _ Luorno MJ, Jakubowicz DJ, Baillargeon JP, et al (2002). http://www.ncbi.nlm.nih.gov/pubmed/15251831 PANIC DISORDERS: 1. Stewart SA. The effects of benzodiazepines on cognition. J Clin Psychiatry. 2005;66(suppl 2):9-13. https://pubmed.ncbi.nlm.nih.gov/1576281 2. "Risks Associated with Long-Term Benzodiazepine Use" by BRIAN JOHNSON, MD, State University of New York Upstate Medical University, Syracuse, New York and JON STRELTZER, MD, University of Hawaii School of Medicine, Honolulu, Hawaii https://www.aafp.org/pubs/afp/issues/2013/0815/p224.html#afp20130815p2243. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorderJ Benjamin 1, J Levine, M Fux, A Aviv, D Levy, R H Belmaker PMID: 7793450 DOI: 10.1176/ajp.152.7.10 https://pubmed.ncbi.nlm.nih.gov/7793450/4. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorderA Palatnik 1, K Frolov, M Fux, J Benjam PMID: 11386498 https://pubmed.ncbi.nlm.nih.gov/1138649